Polynucleotides are an injectable biostimulation treatment composed of purified DNA fragments that act directly on the fibroblasts of the dermis, stimulating the natural production of collagen and elastin. Unlike dermal fillers, they do not add volume: they repair, regenerate, and restructure skin tissue from the deepest layers. At Beldon Beauty Madrid, it is one of the most requested facial rejuvenation treatments due to its high tolerance, natural results, and proven clinical efficacy.
What are Polynucleotides and How Do They Work?
Polynucleotides (PDRN/PN) are nucleic acid chains—fragments of DNA and RNA of biological origin—that act as cellular biostimulators when injected into the dermis. Their mechanism of action is based on three main effects:
- Fibroblast activation: they stimulate the cells responsible for producing collagen, elastin, and endogenous hyaluronic acid
- Tissue regeneration: they repair tissue damaged by aging, the sun, or oxidative stress
- Antioxidant and anti-inflammatory effect: they improve the cellular microenvironment, promoting the structural health of the skin
The result is firmer, hydrated, and more luminous skin that generates its own regenerative resources, without fillers or substances foreign to the biology of the tissue.
Benefits of Polynucleotide Treatment
- Tightening and redensifying effect: fights sagging and improves firmness with visible results from the second session
- Improvement in skin texture and quality: smoothes the surface, minimizes open pores, and fades superficial scars
- Fading of fine wrinkles and expression lines: progressive cellular regeneration reduces signs of aging without blocking natural expression
- Deep hydration and luminosity: the skin regains vitality, radiance, and a healthy appearance from the first session
- 100% natural results: rejuvenation that respects facial features without altering volume or contours
- High tolerance and biocompatibility: suitable for all skin types, including sensitive skin and delicate areas such as the eye contour, neck, and décolletage
Who is it Indicated For?
Polynucleotides are an especially suitable option for:
- People aged 30 to 60 with early or moderate signs of aging (incipient sagging, fine wrinkles, loss of luminosity)
- Skin with a tired, dull appearance or chronic dehydration
- Patients seeking a natural alternative to dermal fillers to improve firmness without adding volume
- People with sensitive skin or who have had intolerance to other injectable treatments
- Those who wish to treat specific areas: face, neck, décolletage, eye contour, or hands
Contraindications
Polynucleotide treatment is not recommended in the following cases:
- Pregnancy and breastfeeding
- Active autoimmune diseases or patients undergoing immunosuppressive treatment
- Active skin infections in the area to be treated
- Known allergy to the components of the product
- Active treatment with anticoagulants (consult with a doctor)
In your assessment consultation at Beldon Beauty, our specialists will evaluate your history and skin condition before starting any protocol.
What the Process is Like at Beldon Beauty Madrid
Treatment protocol
For optimal and long-lasting results, the standard protocol consists of 3 sessions spaced 3-4 weeks apart. From the second month of treatment, the tightening and regenerative effects are progressively consolidated.
| Phase | Detail |
|---|---|
| Preliminary consultation | Skin diagnosis, personalized medical assessment, and protocol design |
| Preparation | Cleansing of the area and application of topical anesthetic cream (20-30 min) |
| Session | Intradermal microinjections in the indicated areas — duration: 30-45 min |
| Immediate post-treatment | Application of calming serum or repairing mask |
| Recovery | Immediate. Possible mild redness or small bruises that disappear in 24-72h |
| Maintenance | 1-2 annual sessions to maintain and prolong results |
Expected results by phase
- After the 1st session: noticeable improvement in hydration and luminosity
- After the 2nd-3rd session: visible tightening effect, improved texture, and reduction of fine wrinkles
- At 2-3 months: consolidation of regeneration; firmer, more uniform, and vital skin
Price of Polynucleotide Treatment in Madrid
The price of polynucleotides in Madrid varies depending on the area to be treated, the type of product used, and the number of sessions in the protocol. At Beldon Beauty, the indicative cost of the facial treatment is from €250 per session. The final price is determined during the personalized assessment consultation, where our specialists design the specific protocol for your skin and your goals.
Frequently Asked Questions about Polynucleotides
Is the polynucleotide treatment painful?
Discomfort is minimal. Before the procedure, a topical anesthetic cream is applied for 20-30 minutes, which makes the microinjections practically painless. The majority of patients at Beldon Beauty describe the sensation as perfectly tolerable.
When are the results of polynucleotides seen?
The results are progressive. Improvement in hydration and luminosity is perceptible from the first session. The tightening and cellular regeneration effect becomes evident from the second and third session, consolidating between 2 and 3 months after the initial protocol.
How many sessions of polynucleotides are needed?
The standard protocol at Beldon Beauty is 3 sessions, one every 3-4 weeks. Afterwards, a maintenance session is recommended every 6-12 months to prolong the results.
What is the difference between polynucleotides and hyaluronic acid?
Hyaluronic acid acts mainly as a filler: it hydrates and replenishes volume in specific areas. Polynucleotides, on the other hand, are a biostimulator that activates the skin's own regenerative capacity to produce collagen, elastin, and endogenous hydration. They are complementary treatments with different goals.
Can polynucleotides be combined with other treatments?
Yes. Polynucleotides are frequently combined with hyaluronic acid, mesotherapy, biorevitalization, or radiofrequency to enhance results. At Beldon Beauty, we design personalized combination protocols based on the needs of each patient.
Do polynucleotides have side effects?
Side effects are mild and transient: slight redness, a feeling of tightness, or small bruises at the injection points, which disappear in 24-72 hours. Since it is a biocompatible treatment, allergic reactions are very rare.
How much does the polynucleotide treatment cost in Madrid?
At Beldon Beauty, the indicative price is from €250 per session for facial treatment. The exact cost of the full protocol is determined during the free assessment consultation, depending on the areas and goals of each patient.
Book Your Polynucleotide Treatment at Beldon Beauty Madrid
If you are looking for real, progressive, and completely natural facial rejuvenation, polynucleotides are the treatment your skin needs. At Beldon Beauty Madrid, our specialists in non-invasive aesthetic medicine design a personalized protocol adapted to your skin type and your goals.
Request your free, no-obligation assessment consultation at Beldon Beauty Madrid.
